Allergy: A Type 1 Hypersensitivity Reaction

Allergy: A Type 1 Hypersensitivity Reaction

An allergy is a medical condition that causes someone to become sick after eating, touching, or breathing something that usually has little or no effect to the average person. The Merriam-Webster dictionary defines “Allergy” as, “exaggerated or pathological immunological reaction (as by sneezing, difficulty breathing, itching, or skin rashes) to substances, situations, or physical states that are without comparable effect on the average individual. “Hypersensitivity” is defined as, abnormally susceptible physiologically to a specific agent (as a drug or antigen). In this article, a type 1 hypersensitivity reaction will be discussed in detail, as well as treatments that can help to reduce the symptoms and potentially cure the allergic reaction completely.

Type 1 hypersensitivity (aka immediate or anaphylactic hypersensitivity) may involve skin, eyes, nasopharynx, bronchopulmonary tissues, and GIT (gastrointestinal tract). The reaction generally takes 15-30 minutes to occur after exposure to the antigen. However, in some cases, it can take 10-12 hours. The symptoms can be anywhere from a minor inconvenience to death.

In a type 1 hypersensitivity reaction, an antigen (a harmful/potentially harmful substance foreign to the body) is presented to CD4 glycoprotein cells (cluster of differentiation cells) and T-helper cells. This stimulates B-cells to produce Immunoglobulin class E (IgE) antibodies specific to the antigen. IgE antibodies then bind to Fc protein receptors on the surface of mast cells and basophils (both rich in histamine and anticoagulant heparin). Mast cells and basophils are then “sensitized” so when a second exposure of the same kind of antigen occurs, this cross links the cell-bound IgE and results in the release of pharmacologically active substances. Cross-linking of IgE Fc-receptor is extremely important in mast cell triggering. Antimicrobial cytotoxic granules are released, calcium ions (Ca2+, signaling transduction) are increased, and histamine (increases the permeability of the capillaries to white blood cells and some proteins to allow them to engage pathogens in the infected tissues), prostaglandin (hormone-like lipid compounds that regulate the contraction and relaxation of smooth muscle tissue), and leukotriene (use lipid signaling to convey information to either the cell producing them or neighboring cells in order to regulate immune responses) are secreted into the surrounding tissue area. Smooth muscle contraction and vasodilation are the main effects in the overall scheme.

Standard Treatments

Type 1 hypersensitivity is classified into an immediate and late-phase reaction. The immediate hypersensitivity reaction occurs minutes after exposure and results in the release of vasoactive amines and lipid mediators. The late-phase reaction occurs 2–4 hours after exposure and includes the release of cytokines (proteins important for cell signaling which impacts cell behavior).

Diagnostic tests include skin tests (skin prick and intradermal) which measure total IgE and specific IgE antibodies against the suspected allergens. Increased IgE levels are indicative of a potential atopic condition (a genetic disposition to develop an allergic reaction and produce elevated levels of IgE upon exposure to an environmental antigen, especially one inhaled or ingested). Symptomatic treatment is given with antihistamines (these block histamine receptors). Chromolyn sodium inhibits mast cell degeneration by inhibiting calcium ion influx (research suggests). Late-phase symptoms are treated with leukotriene receptor blockers or inhibitors of the cyclooxygenase pathway. Singulair and Accolate are leukotriene receptor blockers and Zileutoin are inhibitors of the cyclooxygenase pathway.

Bronchodilators (inhalants) such as isoproterenol derivatives provide short-term symptomatic relief from bronchoconstriction. Terbutaline and Albuterol are used in this case. Hyposensitization, immunotherapy or desensitization, is a treatment for insect venoms and some pollens.

Alternative and Natural Medicine

For many years it has been believed that honey could help relieve allergies by desensitizing allergy sufferers to the pollen in the air. Many scientists argue whether or not honey has a significant impact in treating allergies. However, studies show (by Finnish researchers) that people allergic to birch pollen were able to control their allergy symptoms more than those who used mainstream allergy medication when they consumed honey that contained birch pollen.

Acupuncture has proven to help relieve symptoms and help sufferers breathe better. This has been a successful treatment for many years. However, consistent treatment is required in order to relieve symptoms. When acupuncture treatments stop, the symptoms often times will reappear.

Butterbur is known to a successful natural cure. There is strong evidence supporting its effects. The plants commonly referred to as butterbur are found in the daisy family Asteraceae in the genus Petasites. The herb works as a leukotriene inhibitor. The inhibitor will block some chemicals that cause swelling in the nasal passages. This is a natural remedy that can successfully be used in the place of Singular. Research shows that an extract of butterbur root is just as effective at relieving nasal symptoms as antihistamines like Zyrtec and Allegra. This natural remedy is safer than mainstream medications because it doesn’t cause sleepiness (a common side effects of antihistamines). Many medications are also known to make one restless and uncomfortable. Butterbur, therefore, is a safe and healthy alternative.

There are many other natural remedies that show promising results in treating allergies. Quercetin, found in many fruits and vegetables, works as a mast cell stabilizer. It helps to block histamine that causes inflammation. Studies show great results with quercetin, however, more evidence is being attained to provide more facts. There are other natural treatments that show promising results, yet, more evidence is needed to make it a fact. Some of these natural remedies include, stinging nettle, bromelain (reduces nasal swelling), phleum pratense (helps reduce eye irritation), and tinospora cordifolia (helps reduce sneezing, itching, and nasal discharge). Echinacea, grape seed extract, pine bark extract, vitamin C, cat’s claw, albizzia, baical skullcap, goldenseal, and spirulina are known to help relieve symptoms as well, but more research needs to be conducted in order to make it official.

Knowledge is Power

Understanding what exactly is happening in a type 1 hypersensitivity reaction is crucial in seeking an effective treatment. Now that we understand the process of the reaction, we are armed with sufficient knowledge to start making progress toward a cure. Lots of research is needed to be certain that a particular treatment will be successful.

Many people do not like to take mainstream medications due to the long list of side effects and the potential dangers involved in using some of the medications. Many of these medications DO help relieve symptoms, but the side effects that accompany the treatment can be just as bad as the allergic reaction itself. Albuterol, for example, is known to cause shakiness in the arms and legs and it increases the heart rate for many users. Diarrhea, headache, stomach pain, and nausea are common side effects of many allergy medications.

It is said that in nature, for every plant that causes a negative reaction that there is another plant that will balance it out and provide a cure. While modern society tends to gravitate toward innovative technology for answers, it is unwise to ignore the natural world when seeking help. The more we lose touch with nature, the more we will encounter problems.

The best way to fight against the negative effects of allergies is to embrace the wisdom of the ancients. Getting enough sleep (balanced; not too much not too little), engaging in daily exercise (especially advanced systems like Yoga, Mo Pai Nei Kung, and T’aijiquan), and maintaining a proper diet free of unhealthy chemicals (such as preservatives and artificial flavors), processed foods, and most meat, will naturally build resistance against antigens and will strengthen bodily health to such an extent that one can overcome (or significantly reduce) all allergies. To reach the pinnacle of good health one must maintain a heightened state of consciousness. The more loving, caring, happy, and positive we can be, the better our health will be.

Resources:

http://www.merriam-webster.com/dictionary/allergy

http://abcnews.go.com/Health/Allergies/alternative-allergy-remedies-fact-fiction/story?id=18792233#1

http://www.webmd.com/vitamins-and-supplements/lifestyle-guide-11/allergies-allergy?page=2

http://emedicine.medscape.com/article/136217-treatment

http://www.drugs.com/sfx/albuterol-side-effects.html

http://www.pathlights.com/nr_encyclopedia/

Infection and Immunity article about cigarette smoke

Cigarette Smoke Exposure Impairs Pulmonary Bacterial Clearance and Alveolar Macrophage Complement-Mediated Phagocytosis of Streptococcus pneumoniae

Cigarette smoke exposure increases the risk of pulmonary and invasive infections caused by Streptococcus pneumoniae, the most commonly isolated organism from patients with community-acquired pneumonia. Despite this association, the mechanisms by which cigarette smoke exposure diminishes host defense against S. pneumoniae infections are poorly understood. In this study, we compared the responses of BALB/c mice following an intratracheal challenge with S. pneumoniae after 5 weeks of exposure to room air or cigarette smoke in a whole-body exposure chamber in vivo and the effects of cigarette smoke on alveolar macrophage phagocytosis of S. pneumoniae in vitro. Bacterial burdens in cigarette smoke-exposed mice were increased at 24 and 48 h postinfection, and this was accompanied by a more pronounced clinical appearance of illness, hypothermia, and increased lung homogenate cytokines interleukin-1β (IL-1β), IL-6, IL-10, and tumor necrosis factor alpha (TNF-α). We also found greater numbers of neutrophils in bronchoalveolar lavage fluid recovered from cigarette smoke-exposed mice following a challenge with heat-killed S. pneumoniae. Interestingly, overnight culture of alveolar macrophages with 1% cigarette smoke extract, a level that did not affect alveolar macrophage viability, reduced complement-mediated phagocytosis of S. pneumoniae, while the ingestion of unopsonized bacteria or IgG-coated microspheres was not affected. This murine model provides robust additional support to the hypothesis that cigarette smoke exposure increases the risk of pneumococcal pneumonia and defines a novel cellular mechanism to help explain this immunosuppressive effect.

Full Article: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2825918/

Healthy Living

Internal Arts

Nei Jia is a system of work that allows for the cultivation of heath and longevity in a balanced state of peace, attainment, and tranquillity. Nei Jia is an enlightened system that leads to the highest end when fully embodied and understood. The attainment of physical and mental/spiritual health and well being allows for intellectual growth and consciousness expansion. Many who fully embody the physical and mental/spiritual aspects of Nei Jia go beyond in their experience. My friend and brother Shifu Micah David (Hern Heng) has been blessed to learn from great masters of the art. To learn more please visit http://wkfhf.com/neijiakungfu.com/ Ask about training opportunities! Regular seminars are held in various locations in the United States.

The following are relevant lineages of the Nei Jia taught at Three Temples Kung Fu and Tactical Training. Other systems’ lineages are available by request. If you are curious about a system we teach not listed here, just ask!
Contact info: ThreeTemples@gmail.com

 

Hebei Style Xingyiquan (Black Sash, Instructor Ranking) xingyi

Chen Style Taijiquan (Black Sash, Instructor Ranking) chen-lines

 

Yang Style Taijiquan (Black Sash, Instructor Ranking) yang-lines

 

Chen, Pan-Ling Style Taijiquan (Permission to teach)

 

Cheng Style Baguazhang (Permission to teach) bagua

Traditional Northern Celestial Mountain Kung Fu (Black Sash, Instructor Ranking), basis for the Three Temples Internal Kung Fu 18 Forms

calibrations

Just some thoughts…

How much does mental health impact physical health?

If we consider the emotional state of an individual who has just received news that a close loved one has suddenly died, most people would respond in a state of sadness and sorrow. In times of extreme grief, the impact of the mind on the body can be harsh and long lasting. In grief, despair, and sorrow, the mind is “sick.” The body naturally embodies the sickness, as a shadow follows one walking in light.

If that person were able to gain command over his or her mind, he or she would come to make peace with all reality and settle into a balanced and healthy state of mind functioning in good mental and physical health.

Cultivating a more focused mind, harmoniously aligned with the universal laws of morality, will allow greater consciousness expansion and intellectual development.

Overcoming grief requires liberation from false ideas. Letting go of all despair and finding peace is difficult for most people. Many people suffer miserably with bad health, physically and mentally.

Understanding the mysteries of life will enable people to take control of their health and well being. Knowledge is power. The truth removes the barriers of growth and allows an avenue for one to attain total freedom and liberation. Bringing our emotional minds into a harmonious balance will help us transcend all sickness. As in the example of the person receiving news of a loved one’s death, this person may fall into extreme despair and this can lead to destruction. However if one knew that no one really dies, then one would have no need to fall into a state of extreme despair/suffering.

Maintaining regular exercise will help one begin to regulate and balance the bodily system. Focusing on good health and being disciplined will provide an opportunity for positive change. When done in a harmonious manner, exercise will help one rise up from despair and relax. Most people suffer from varying degrees of stress and all the reasons for it. Being aware of this, the way to overcoming it is to focus on regulating all stress through elimination and balancing the mind in equanimity. Relaxing all tension, letting all stress go. Gently and with grace.

Understanding the difference between the body and the mind will allow one to attain a greater command of one’s health if one is disciplined enough to maintain discipline. It requires work, not too much, not too little.

Aligning one’s mind with the living power that sustains all life will allow one to begin to know the creator of reality and this leads to the highest end. It is mighty and powerful, and it is silent and elusive.

The power that gives life

Do you believe it’s possible that SOMETHING created the universe and all existence? Is it possible that a power greater than the universe exists?

-“yes, God is the creator of all existence, God alone commands all…”

-“How did the universe come into existence? That’s a hard one, but evidence suggests that the giver of life is controlling the universe, which makes it a greater power than the universe.”

-“SOMETHING HAD to have made life!! Louis Pasteur disproved spontaneous generation of microorganisms, life doesn’t arise from nothing. The universe too, didn’t arise from nothing. The SOMETHING that brought the universe into existence is what most people in America refer to as GOD. The universe came from SOMETHING. That something is a power greater than the universe and what is known to mankind.”

-“How did we get here? I think the answer is so BIG that we would have difficulty wrapping our minds around it.”

-“I definately believe it’s possible. At our core we are but the light of consciousness. A power gives life to that light.”

-“Our people believe that the power that gives life is alive and we communicate with it and we give thanks for life and all the blessings of life. We live our lives in thanks and gratitude. It is a power that is greater than the universe…”

-“יהוה alone gives life to the universe. יהוה alone has power over all.”

Honey offers a successful approach to fighting antibiotic resistance

Honey, that delectable condiment for breads and fruits, could be one sweet solution to the serious, ever-growing problem of bacterial resistance to antibiotics, researchers said in Dallas today.

Honey could be one sweet solution to the serious, ever-growing problem of bacterial resistance to antibiotics, researchers said in Dallas* today. Medical professionals sometimes use honey successfully as a topical dressing, but it could play a larger role in fighting infections, the researchers predicted.

“The unique property of honey lies in its ability to fight infection on multiple levels, making it more difficult for bacteria to develop resistance,” said study leader Susan M. Meschwitz, Ph.D. That is, it uses a combination of weapons, including hydrogen peroxide, acidity, osmotic effect, high sugar concentration and polyphenols — all of which actively kill bacterial cells, she explained. The osmotic effect, which is the result of the high sugar concentration in honey, draws water from the bacterial cells, dehydrating and killing them.

In addition, several studies have shown that honey inhibits the formation of biofilms, or communities of slimy disease-causing bacteria, she said. “Honey may also disrupt quorum sensing, which weakens bacterial virulence, rendering the bacteria more susceptible to conventional antibiotics,” Meschwitz said. Quorum sensing is the way bacteria communicate with one another, and may be involved in the formation of biofilms. In certain bacteria, this communication system also controls the release of toxins, which affects the bacteria’s pathogenicity, or their ability to cause disease.

Meschwitz, who is with Salve Regina University in Newport, R.I., said another advantage of honey is that unlike conventional antibiotics, it doesn’t target the essential growth processes of bacteria. The problem with this type of targeting, which is the basis of conventional antibiotics, is that it results in the bacteria building up resistance to the drugs.

Honey is effective because it is filled with healthful polyphenols, or antioxidants, she said. These include the phenolic acids, caffeic acid, p-coumaric acid and ellagic acid, as well as many flavonoids. “Several studies have demonstrated a correlation between the non-peroxide antimicrobial and antioxidant activities of honey and the presence of honey phenolics,” she added. A large number of laboratory and limited clinical studies have confirmed the broad-spectrum antibacterial, antifungal and antiviral properties of honey, according to Meschwitz.

She said that her team also is finding that honey has antioxidant properties and is an effective antibacterial. “We have run standard antioxidant tests on honey to measure the level of antioxidant activity,” she explained. “We have separated and identified the various antioxidant polyphenol compounds. In our antibacterial studies, we have been testing honey’s activity against E. coliStaphylococcus aureus and Pseudomonas aeruginosa, among others.”

*This study was presented the 247th National Meeting of the American Chemical Society (ACS).

http://www.sciencedaily.com/releases/2014/03/140316132801.htm

One Love

p805201086-4.jpg (800×534)vashikaran-guru.jpg (372×353)

 

Eating organic food protects from pesticide exposure

Eating organic food protects from pesticide exposure

Filed Under: Pesticides Organics Health Children
Children who switched to eating organically-grown food greatly reduced their exposure to organophosphate insecticides. Scientists from Seattle and Atlanta just published the results of their study which linked pesticides in children’s urine to pesticide residues on food. Scientists worry that organophosphates might harm children’s developing nervous systems.

Children who switched to eating organically-grown food greatly reduced their exposure to organophosphate insecticides. Scientists from Seattle and Atlanta just published the results of their study which linked pesticides in children’s urine to pesticide residues on food. Scientists worry that organophosphates might harm children’s developing nervous systems.

Twenty-three elementary-aged children participated in a 15 day study which was divided into three parts. First the children ate their usual diet of conventionally-grown food for 3 days. Then they were switched to organically-grown substitutes for 5 days. For the final 7 days, they switched back to conventional food.

The organic substitutes were mainly fruits, vegetables, juices, and grain products (such as wheat) because these foods are often contaminated with organophosphates.

Urine samples were collected twice a day for each child. Researchers tested the urine for signs of pesticides.

In the case of two organophosphate insecticides — malathion and chlorpyrifos — the results were startling. Signs of these two chemicals were found in the urine in the first part of the study. Almost immediately after the children switched to an organic diet, these chemicals could not be detected. The chemicals showed up again when the children switched back to their normal diet.

The researchers said “We were able to demonstrate that an organic diet provides a dramatic and immediate protective effect against exposures to organophosphorus pesticides that are commonly used in agriculture.”

More information on chlorpyrifos

The organophosphate family of chemicals damages the nervous system (which includes the brain), so scientists are particularly concerned about children’s exposure because their bodies are still developing. Chlorpyrifos is one of the many insecticides in this chemical family.

In 1999, the Environmental Protection Agency decided to start cancelling some uses of chlorpyrifos, in part because of some disturbing animal studies. For example, newborn rats were much more susceptible to toxic effects of chlorpyrifos than adults. Also, even low doses of chlorpyrifos caused structural changes in the development of the brain.

While chlorpyrifos has been greatly restricted for uses in and around homes, it is still widely used in agriculture. The study described above makes it clear that children are still exposed to chlorpyrifos from residues on food.

http://www.pesticide.org/the-buzz/eating-organic-food-protects-children-from-pesticide-exposure

the power of pure/positive thought

i-hate-you-1050x787

 

Dr. Masaru Emoto, a researcher and alternative healer from Japan has given the world a good deal of evidence of the magic of positive thinking. He became famous when his water molecule experiments featured in the 2004 film, What The Bleep Do We Know? His experiments demonstrate that human thoughts and intentions can alter physical reality, such as the molecular structure of water. Given that humans are comprised of at least 60% water, his discovery has far reaching implications… can anyone really afford to have negative thoughts or intentions.

The rice experiment is another famous Emoto demonstration of the power of negative thinking (and conversely, the power of positive thinking.) Dr Emoto placed portions of cooked rice into two containers. On one container he wrote “thank you” and on the other “you fool”. He then instructed school children to say the labels on the jars out loud everyday when they passed them by. After 30 days, the rice in the container with positive thoughts had barely changed, while the other was moldy and rotten.

After watching this video, we have to ask ourselves…if our thoughts can do that to the water and rice?.. then what do our thoughts do to our body??? It seems clear that negative/impure thoughts damage our body. The more we allow our minds to dwell in negativity and impurity, the worse the damage is. The more we keep our minds on pure/positive thoughts, the more we can enhance our health and well-being.

http://countercurrentnews.com/2014/01/scientific-proof-thoughts-intentions-can-alter-the-physical-world-around-us/

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